Parp Inhibitor Breast Cancer Side Effects

Here two oncology pharmacists discuss the side effects of parp inhibitor treatment and how to prevent and treat nausea and vomiting in this patient population.

Parp inhibitor breast cancer side effects.

See below for a comprehensive list of adverse effects. Upper respiratory tract infection anemia decreased hemoglobin increased mcv increased serum creatinine nasopharyngitis nausea pharyngitis vomiting cough and dyspnea. Side effects of parp inhibitors. Introduction poly adp ribose polymerase parp inhibitors are a class of oral anticancer medications that have the most evidence for use in patients with inherited germline mutations.

Ursula matulonis chief of gynecologic oncology at the dana farber cancer institute to learn more about these potential side effects. And low white blood cell counts. Parp inhibitors are a type of targeted cancer drug. They are a treatment for some women with ovarian cancer.

In general parp inhibitors cause fewer and less serious side effects than some other cancer treatments. They are developed for multiple indications including the treatment of heritable cancers. Lung and airway infection or inflammation. Commonly reported side effects of olaparib include.

Headache they can also cause low red blood cell counts called anemia which can lead to fatigue and other problems. Based on clinical trial results the national comprehensive cancer network nccn added lynparza as a preferred treatment for people with advanced breast cancer and a brca mutation. Parp is a protein found in our cells it stands for poly adp ribose polymerase. Side effects requiring immediate medical attention.

Parp inhibitors for treating breast cancer lynparza and talzenna have received fda approval for treating metastatic breast cancer caused by a brca mutation. Several forms of cancer are more dependent on parp than regular cells making parp parp1 parp2 etc an attractive target for cancer therapy parp inhibitors appear to improve progression free. We spoke to dr. The side effects of parp inhibitors can usually be controlled or reduced and those described here will not affect everyone.

They are also in trials as a treatment for other types of cancer. Parp inhibitors are a group of pharmacological inhibitors of the enzyme poly adp ribose polymerase parp. Like any drugs parp inhibitors can cause side effects and different ones will have varying effects. Common parp inhibitor side effects.

All parp inhibitors are swallowed as a pill and the timing and dosage of the drug varies based on which type of parp inhibitor you re prescribed.